Combined anticonvulsant activity of verapamil and phenobarbitone in mice

ABSTRACT

This study aimed to investigate the anticonvulsant activity of different combinations of phenobarbitone and verapamil. The effect of intraperitoneal[ip] administration of verapamil into mice in a dose of 10 mg/kg on the anticonvulsant activity of phenobarbitone [PB] injected ip in doses of 10, 20, 30 and 40 kg/mg was investigated. Verapamil was allowed to act for five minutes and phenobarbitone for thirty minutes prior to injection of the convulsive agents. Verapamil was given either alone or in combination with different doses of phenobarbitone. Convulsions were induced in animals by pentylenetetrazole [PTZ] in a dose of 100 mg/kg or by strychnine in a dose of 1 mg/kg