Cromoglycate: a healing agent in acute chlorine-induced lung damage
DARU-Journal of Faculty of Pharmacy Tehran University of Medical Sciences. 2002; 10 (3): 120-4
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| ID: emr-59119
Biblioteca responsável:
EMRO
ABSTRACT
In the present study the effectiveness of sodium cromoglycate in treatment of alveolar damage induced by chlorine gas in rats was investigated. Chlorine was generated by chemical interaction between potassium permanganate and concentrated hydrochloric acid. The rats were exposed to sublethal dose of chlorine gas. Treatment with 2.5 mg of 1 ml nebulized sodium cromoglycate solution over 5 minutes was initiated 30 minutes after exposure followed by twice daily treatment for 21 days. Results of this study show that cromoglycate reduced alveolar thickness, septal rupture, hemorrhage and detachment of the epithelial lining of the bronchioles induced by chlorine gas
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Índice:
IMEMR
Assunto principal:
Ratos
/
Cloro
/
Doença Aguda
/
Pneumopatias
Limite:
Animals
Idioma:
En
Revista:
J. Fac. Pharm. Tehran Univ. Med. Sci.
Ano de publicação:
2002