Medical Journal of Cairo University [The]. 2008; 76 (4): 743-753
em En
| IMEMR
| ID: emr-88899
Biblioteca responsável:
EMRO
ABSTRACT
There is still uncertainty about angiogenesis as a prognostic factor in breast cancer. To evaluate the prognostic value of microvascular density [MVD] in breast carcinoma and soluble vascular cell adhesion molecule-1 [sVCAM-1], leptin, estradiol and total testosterone as angiogenic markers. Efficacy of shark care drug was assessed by patient's overall survival. 30 premenopausal breast cancer patients [group II] and 15 controls [group I]. Group II was subgrouped into 15 patients receiving chemotherapy alone [IIA] and 15 patients receiving chemotherapy + shark care drug [IIB]. After modified radical mastectomy, microvessels were counted by staining tissues for factor VIII. For surrogate markers, enzyme-linked immunosorbant assay or radiommunoassay kits were used. A high MVD was found only in areas of carcinoma. MVD and sVCAM-1 correlated significantly with each other and with lymph node involvement. After the follow-up, all subgroup IIB patients were alive compared to 66.6% of subgroup IIA [p=0.02]. A high MVD may be a poor prognostic marker of breast carcinoma and a target for antiangiogenic therapy sVCAM-1 is useful for diagnosis and for monitoring response to therapy. Chemotherapy + shark care drug seem to ameliorate the outcome of these patients
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Índice:
IMEMR
Assunto principal:
Testosterona
/
Imuno-Histoquímica
/
Mastectomia Radical
/
Pré-Menopausa
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Molécula 1 de Adesão de Célula Vascular
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Leptina
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Inibidores da Angiogênese
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Estradiol
/
Neovascularização Patológica
Limite:
Female
/
Humans
Idioma:
En
Revista:
Med. J. Cairo Univ.
Ano de publicação:
2008