Mechanism of enhancement of renal (Na+ + K+) ATPase activity following chronic ethanol exposure
Acta physiol. pharmacol. ther. latinoam
; 46(1): 49-56, 1996. ilus, tab, graf
Article
em En
| LILACS
| ID: lil-168106
Biblioteca responsável:
BR1.1
ABSTRACT
A method was devised to determine the nature of the mechanism of the increase in renal (NA++K+)-ATPase in rats fed dilute ethanol for ten weeks. Antiserum to (NA++K+)-ATPase obtained from rabbits was added to microssomal fractions of Kidney and the activities of (NA++K+)-ATPase and Mg2+ ATPase were determined. The addition of antiserum resulted in a same pattern of dose-related inhibition of (NA++K+)-ATPase activity in control and ethanol-fed rats, whereas mg2+-ATPase was not affected by the antiserum. These results suggest that the mechanism of ethanol-induced enhancement of renal (NA++K+)-ATPase activity could be explained through an increase in the number of catalytic units.
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Índice:
LILACS
Assunto principal:
ATPase Trocadora de Sódio-Potássio
/
Etanol
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Acta physiol. pharmacol. ther. latinoam
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Ano de publicação:
1996
Tipo de documento:
Article
/
Project document