Correlación entre la presencia de anticuerpos y antígeno de citomegalovirus en los leucocitos de sangre para el diagnóstico de la infección activa primaria / Cytomegalovirus infection diagnosis measuring antibodies against the virus or the antigen presence in peripheral leukocytes
Rev. méd. Chile
; 126(5): 533-7, mayo 1998. tab
Article
em Es
| LILACS
| ID: lil-216438
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
The diagnosis of cytomegalovirus infections measuring IgG or IgM antibodies has a high rate of false positive or negative results, specially in immunocompromised patients.Aim:
To compare the diagnostic yield of antibodies against cytomegalovirus with the measurement of the antigen in peripheral leukocytes. Material andmethods:
Forty three blood samples coming from pediatric patients with suspected cytomegalovirus infections were analyzed. Low affinity IgG and IgM antibodies against Epstein Barr virus and cytomegalovirus, using indirect ELISA assays, and the virus antigen in peripheral leukocytes, using a commercial immunoperoxidase assay, were measured.Results:
Seven patients had positive IgM antibodies against cytomegalovirus. In five of these the viral antigen was detected in peripheral leukocytes. Twenty patients had positive antibodies against Epstein Barr virus, and in 16 patients all serologic tests were negative.Conclusions:
There is not a good correlation between antibodies against cytomegalovirus and the detection of its antigen in patients with acute infections
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Índice:
LILACS
Assunto principal:
Infecções por Citomegalovirus
/
Citomegalovirus
/
Leucócitos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article