Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches
Mem. Inst. Oswaldo Cruz
; 93(supl.1): 141-51, Oct. 1998. ilus, tab
Article
em En
| LILACS
| ID: lil-218655
Biblioteca responsável:
BR15.1
RESUMO
The authors present morphogenetic and biomechanical approaches on the concept of the Schistosoma mansoni granulomas, considering them as organoid structures that depend on cellular adhesion and sorting, forming rearrangement into hierarchical concentric layers, creating tension-dependent structures, aiming to acquire round form, since this is the minimal energy form, in which opposing forces pull in equally from all directions and are in balance. From the morphogenetic point of view, the granulomas function as little organs, presenting maturative and involutional stages in their development with final disappearance (pre-granulomatous stages, subdivided in weaky and/or initial reactive and exudative; granulomatous stages exudative-productive, productive and involutional). A model for the development of granulomas was suggested according to the following stages encapsulating, focal hystolysis, fiber production, orientation and compacting and involution and desintegration. The autors concluded that schistosomal granuloma is not a tangled web of individual cells and fibers, but an organized structure composed by host and parasite components, which is not formed to attack the miracidia, but functions as an hybrid interface between two different phylogenetic beings.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Schistosoma mansoni
/
Fenômenos Biomecânicos
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Fibrose
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Matriz Extracelular
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Granuloma
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Morfogênese
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
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Congress and conference