Efectos de la administración aguda y subaguda de extractos de Pimenta dioica (Myrtaceae) en rata albinas normotensas e hipertensas / Effect of acute and subacute administration of Pimenta dioica (Myrtaceae)

ABSTRACT

The intraperitoneal administration of different extracts of Pimenta dioica (L.) Merrill (Myrtaceae) to conscious normotensive and hypertensive rats caused a depression of the central nervous system (CNS). The intensity of this depression depends on the dose. Analgesic and hypothermic effects were also observed. The total aqueous extract was more effective than the ethanolic extract and the final aqueous fraction was the most effective. The peritoneal irritation caused by the extract explains only partially the depressive effect over the CNS. When the final aqueous fraction was given orally to SDN and SHR rats during 14 days there was no observed change on the sistolic blood pressure, heart rate and weight of the animals