Efeito do carvedilol na insuficiência cardíaca por cardiomiopatia dilatada: resultado de estudo duplo-cego, randômico, com grupo placebo-controle (estudo CARIBE) / Effects of carvedilol in heart failure due to dilated cardiomyopathy: results of a double-blind randomized placebo-controlled study (CARIBE study)
Arq. bras. cardiol
; 74(3): 233-42, mar. 2000. tab, graf
Article
em Pt, En
| LILACS
| ID: lil-265165
Biblioteca responsável:
BR1.1
RESUMO
OBJECTIVE:
To assess the effects of carvedilol in patients with idiopathic dilated cardiomyopathy.METHODS:
In a double-blind randomized placebo-controlled study, 30 patients (7 women) with functional class II and III heart failure were assessed. Their ages ranged from 28 to 66 years (mean of 43ñ9 years), and their left ventricular ejection fraction varied from 8 per cnet to 35 per cent. Carvedilol was added to the usual therapy of 20 patients; placebo was added to the usual therapy of 10 patients. The initial dose of carvedilol was 12.5 mg, which was increased weekly until it reached 75 mg/day, according to the patient's tolerance. Clinical assessment, electrocardiogram, echocardiogram, and radionuclide ventriculography were performed in the pretreatment phase, being repeated after 2 and 6 months of medication use.RESULTS:
A reduction in heart rate (p=0.016) as well as an increase in left ventricular shortening fraction (p=0.02) and in left ventricular ejection fraction (p=0.017) occurred in the group using carvedilol as compared with that using placebo.CONCLUSION:
Carvedilol added to the usual therapy for heart failure resulted in better heart function.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Volume Sistólico
/
Carbazóis
/
Baixo Débito Cardíaco
/
Cardiomiopatia Dilatada
/
Antagonistas Adrenérgicos beta
/
Frequência Cardíaca
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
/
Pt
Revista:
Arq. bras. cardiol
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article