HPLC identification of isoniazid residues in bovine milk
Arq. bras. med. vet. zootec
; 52(6): 662-8, dez. 2000. ilus, tab
Article
em En
| LILACS
| ID: lil-283479
Biblioteca responsável:
BR68.1
ABSTRACT
The high pressure liquid chromatography (HPLC) was used for the identification of isoniazid (isonicotinic acid hydrazide) in the milk of cattle treated with a dose of 25 mg/kg/day in alternated days. The effect of milk pasteurization on the isoniazid residue concentration was also studied. The drug excretion presented a cyclic variation, with higher levels in the first day after administration (aa), a mean of 1104.48µg/l, and a decrease two days aa, with a mean of 104.12µg/l. Four days after the last administration of the drug it was not possible to identify residues of isoniazid in the milk of treated animals. Body weight and milk yield influenced the amount of the excreted drug, and pasteurization decreased (mean 47.07 per cent) the concentration of isoniazid residue in milk
Texto completo:
1
Índice:
LILACS
Assunto principal:
Tuberculose Bovina
/
Leite
/
Isoniazida
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Arq. bras. med. vet. zootec
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2000
Tipo de documento:
Article