Effects of central imidazolinergic and alpha2-adrenergic activation on water intake
Braz. j. med. biol. res
; 34(9): 1185-1190, Sept. 2001. graf
Article
em En
| LILACS
| ID: lil-290395
Biblioteca responsável:
BR1.1
RESUMO
Non-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed ligands binding to I-R/alpha2-AR such as guanabenz (40 nmol) and UK 14304 (20 nmol) inhibited water intake by 65 percent and up to 95 percent, respectively. The selective non-imidazoline alpha2-AR agonist, alpha-methylnoradrenaline, produced inhibition of water intake similar to that obtained with guanabenz, but at higher doses (80 nmol). The non-adrenergic I-R ligands histamine (160 nmol, mixed histaminergic and imidazoline ligand) and imidazole-4-acetic acid (80 nmol, imidazoline ligand) did not alter water intake. The results show that selective, non-imidazoline alpha2-AR activation suppresses water intake, and suggest that the action on imidazoline sites by non-adrenergic ligands is not sufficient to inhibit water intake
Texto completo:
1
Índice:
LILACS
Assunto principal:
Quinoxalinas
/
Nordefrin
/
Receptores Adrenérgicos alfa 2
/
Ingestão de Líquidos
/
Guanidinas
/
Imidazóis
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2001
Tipo de documento:
Article