Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
; 56(5): 139-142, Sept.-Oct. 2001. tab
Article
em En
| LILACS
| ID: lil-305074
Biblioteca responsável:
BR1.1
ABSTRACT
Bone is an androgen-dependent tissue, but it is not clear whether the androgen action in bone depends on testosterone or on dihydrotestosterone. Patients with 5alpha-reductase 2 deficiency present normal levels of testosterone and low levels of dihydrotestosterone, providing an in vivo human model for the analysis of the effect of testosterone on bone. OBJECTIVE:
To analyze bone mineral density in 4 adult patients with male pseudohermaphroditism due to 5alpha-reductase 2 deficiency.RESULTS:
Three patients presented normal bone mineral density of the lumbar column (L1-L4) and femur neck, and the other patient presented a slight osteopenia in the lumbar column.CONCLUSION:
Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone
Texto completo:
1
Índice:
LILACS
Assunto principal:
Transtornos do Desenvolvimento Sexual
/
3-Oxo-5-alfa-Esteroide 4-Desidrogenase
/
Densidade Óssea
Limite:
Adult
/
Humans
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Male
Idioma:
En
Revista:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Assunto da revista:
MEDICINA
Ano de publicação:
2001
Tipo de documento:
Article