Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
Arq. neuropsiquiatr
; 61(3B): 851-854, Sept. 2003. ilus, tab
Article
em En
| LILACS
| ID: lil-348677
Biblioteca responsável:
BR1.1
ABSTRACT
The frequency of myopathy in hypothyroidism ranges from 30 to 80 percent. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case
Texto completo:
1
Índice:
LILACS
Assunto principal:
Músculo Esquelético
/
Hipotireoidismo
/
Doenças Musculares
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Arq. neuropsiquiatr
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2003
Tipo de documento:
Article