Effects of a high molecular mass Convolvulus arvensis extract on tumor growth and angiogenesis
P. R. health sci. j
; P. R. health sci. j;21(4): 323-338, Dec. 2002.
Article
em En
| LILACS
| ID: lil-356232
Biblioteca responsável:
BR1.1
RESUMO
BACKGROUND:
Plant materials represent promising sources of anti-cancer agents. We developed and tested a novel extract from the ubiquitous plant Convolvulus arvensis. MATERIALS ANDMETHODS:
Convolvulus arvensis components were extracted in boiling water, and small molecules were removed by high-pressure filtration. The extract's biological activity was assessed by measuring its effects on S-180 fibrosarcoma growth in Kun Ming mice and on heparin-induced angiogenesis in chick embryos. We also examined the extract's effects on lymphocytes ex vivo and tumor cell growth in vitro.RESULTS:
The extract (primarily proteins and polysaccharides) inhibited tumor growth in a dose-dependent fashion when administered orally. At the highest dose tested, 200 mg/kg/day, tumor growth was inhibited by roughly seventy percent. Subcutaneous or intraperitoneal administration at 50 mg/kg/day also inhibited tumor growth by over seventy percent. The extract's acute LD50 in Kun Ming mice was 500 mg/kg/day when injected, indicating that tumor growth inhibition occurred at non-toxic doses. It inhibited angiogenesis in chick embryos, improved lymphocyte survival ex vivo, and enhanced yeast phagocytosis, but did not kill tumor cells in culture.CONCLUSION:
High molecular mass extract deserves further study as an anti-cancer agent.
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Índice:
LILACS
Assunto principal:
Preparações de Plantas
/
Convolvulus
/
Fitoterapia
/
Neoplasias
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
P R Health Sci J
/
P. R. health sci. j
/
Puerto Rico health sciences journal
/
Puerto Rico health sciences journal (Online)
Assunto da revista:
MEDICINA
Ano de publicação:
2002
Tipo de documento:
Article