Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice
Mem. Inst. Oswaldo Cruz
; 99(3): 289-294, May 2004. graf
Article
em En
| LILACS
| ID: lil-361997
Biblioteca responsável:
BR1.1
RESUMO
Resistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN-gamma) deficient (-/-) mice inoculated L. braziliensis develop severe uncontrolled lesions, chronic lesions that remained under control up to 12 weeks of infection were observed in IL-12p40 -/- mice. IL 12p40 -/- mice had fewer parasites in their lesions than IFN-gamma-/- mice. Lymph node cells from IL-12p40 -/- were capable of producing low but consistent levels of IFN-gamma suggestive of its involvement in parasite control. Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL-12p40 -/- infected with L. braziliensis.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Leishmania braziliensis
/
Interferon gama
/
Leishmaniose Cutânea
/
Interleucina-12
Tipo de estudo:
Prognostic_studies
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article