Preliminary studies with a neurotoxin obtained from Bungarus caeruleus venom
J. venom. anim. toxins incl. trop. dis
; J. venom. anim. toxins incl. trop. dis;12(1): 78-90, 2006. ilus, graf
Article
em En
| LILACS, VETINDEX
| ID: lil-423836
Biblioteca responsável:
BR68.1
RESUMO
The neurotoxin purified from the venom of Bungarus caeruleus causes a neuromuscular blockade on acetylcholine-induced muscle twitch response in isolated frog rectus abdominis muscle preparation. Neuromuscular blockade produced by d-tubocurarine on acetylcholine-induced muscle twitch response in an isolated frog rectus abdominis muscle preparation was reversed to normal muscle twitch response in presence of neostigmine. Whereas the purified neurotoxin produced an irreversible neuromuscular blockade in presence of the same strength of neostigmine. As it is already known, botulinum toxin, which also brings about neuromuscular blockade, is effectively used as a drug in the treatment of painful movement disorders. Since the purified toxin also causes paralysis of the muscle, we propose its possible efficacy in the treatment of neuromuscular disorders.(AU)
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Bungarus
/
Bloqueio Neuromuscular
/
Neurotoxinas
Idioma:
En
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article