Influence of antisperm antibodies in the semen on intracytoplasmic sperm injection outcome
Int. braz. j. urol
;
33(6): 795-802, Nov.-Dec. 2007. tab
Artigo
em Inglês
| LILACS
| ID: lil-476643
ABSTRACT
OBJECTIVE:
The aim of this study was to analyze the influence of autoantibodies against spermatozoa present in the semen on the outcome of in vitro fertilization with intracytoplasmic sperm injection (ICSI). MATERIALS ANDMETHODS:
We performed a retrospective analysis of clinical and laboratorial data from a six year-period ICSI cycles. Screening for the presence of ASA in the semen, by using the direct immunobeads test (IBT), was available for 351 cycles. According to the percentage of antibody-bound spermatozoa in the semen, we divided the cycles in four groups I (n = 194) 0 percent-10 percent ASA; II (n = 107) 11 percent-20 percent; III (n = 33) 21 percent-50 percent and IV (n = 17) 51 percent-100 percent ASA. Additionally, a group of 349 ICSI cycles performed with ejaculated spermatozoa from oligo/asthenozoospermic men who had insufficient number of motile sperm available for ASA screening was included for comparison. ICSI outcomes were compared among groups and included fertilization rate (2 PN), cleavage rate, cleavage velocity, embryo quality, clinical pregnancy and miscarriage rates. Data were examined statistically, with an alpha level of 5 percent considered significant.RESULTS:
Fertilization, cleavage rate and velocity, percentage of good quality embryos, as well as clinical pregnancy and miscarriage rates did not differ among different ASA levels groups. ICSI outcomes in men exhibiting different levels of autoimmunity against spermatozoa did not differ from those with severely abnormal seminal parameters.CONCLUSIONS:
Our data indicate that intracytoplasmic sperm injection (ICSI) outcomes are not influenced by ASA levels on sperm.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Sêmen
/
Espermatozoides
/
Injeções de Esperma Intracitoplásmicas
/
Infertilidade Masculina
/
Anticorpos
Tipo de estudo:
Estudo observacional
Limite:
Feminino
/
Humanos
/
Masculino
/
Gravidez
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Male Reproduction Reference Center/BR
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