Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
Clinics
; 64(7): 669-674, 2009. ilus, tab
Article
em En
| LILACS
| ID: lil-520800
Biblioteca responsável:
BR1.1
ABSTRACT
The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS:
Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions.RESULTS:
No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient.CONCLUSIONS:
Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Cloreto de Sódio
/
Refluxo Gastroesofágico
/
Esofagite
/
Esôfago
/
Espaço Extracelular
/
Ácido Clorídrico
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2009
Tipo de documento:
Article