Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile / Seroprevalence of hepatitis B virus in children with cancer under chemotherapy in 6 hospitals of Santiago, Chile
Rev. méd. Chile
; 137(7): 906-911, jul. 2009. tab
Article
em Es
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| ID: lil-527129
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
Children under oncological therapy are at risk of infection by hepatitis B virus (HBV).Aim:
To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant. Material andmethods:
Collaborative, multi-centric study. Serum samples were collected from 281 children with cancer and episodes of febrile neutropenia, from 6 hospitals belonging to the public health network in the Metropolitan Region, between June 2004 and August 2006. These samples were stored at -70-'C. In September 2006, 200 samples were randomly chosen and 170 analyzed to determine hepatitis B virus surface antigen (HBsAg) and anticore total antibodies (anti HBc) by fluorescent ELISA (Enzyme Linked Immunosorbent Assay). In five cases in which a low volume of sample was available, only one marker was studied (HBsAg in two and anti HBc in three).Results:
Samples carne from children aged 4 months to 18 years, 104 males (61 percent). They had received an average of 38 transfusions (range 3-107) from 65 donors (range 3-345). Twelve children were found positive for some marker of HBV HBsAg in three (1.8 percent) and anti HBc in ten (7 percent). In 5 patients that had negative HBsAg and positive anti HBc, anti surface antigen antibodies (anti HBs) were determined and resulted positive in fourConclusions:
The prevalence of HBV in this sample was 7 percent if both serologic markers are considered and 1.8 percent if only HBsAg is considered.Palavras-chave
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LILACS
Assunto principal:
Hepatite B
/
Anticorpos Anti-Hepatite B
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Antígenos de Superfície da Hepatite B
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Neoplasias
/
Antineoplásicos
Tipo de estudo:
Clinical_trials
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
America do sul
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Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2009
Tipo de documento:
Article
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Project document