Metabolism of a lipid nanoemulsion resembling low-density lipoprotein in patients with grade III obesity
Clinics
; 65(1): 23-27, 2010. tab, graf
Article
em En
| LILACS
| ID: lil-538603
Biblioteca responsável:
BR1.1
ABSTRACT
Introduction:
Obesity increases triglyceride levels and decreases high-density lipoprotein concentrations in plasma. Artificial emulsions resembling lipidic plasma lipoprotein structures have been used to evaluate low-density lipoprotein metabolism. In grade III obesity, low density lipoprotein metabolism is poorly understood.Objective:
To evaluate the kinetics with which a cholesterol-rich emulsion (called a low-density emulsion) binds to low-density lipoprotein receptors in a group of patients with grade III obesity by the fractional clearance rate.Methods:
A low-density emulsion was labeled with [14C]-cholesterol ester and [³H]-triglycerides and injected intravenously into ten normolipidemic non-diabetic patients with grade III obesity [body mass index higher than 40 kg/m²] and into ten non-obese healthy controls. Blood samples were collected over 24 hours to determine the plasma decay curve and to calculate the fractional clearance rate.Results:
There was no difference regarding plasma levels of total cholesterol or low-density lipoprotein cholesterol between the two groups. The fractional clearance rate of triglycerides was 0.086 ± 0.044 in the obese group and 0.122 ± 0.026 in the controls (p = 0.040), and the fractional clearance rate of cholesterol ester (h-1) was 0.052 ± 0.021 in the obese subjects and 0.058 ± 0.015 (p = 0.971) in the controls.Conclusion:
Grade III obese subjects exhibited normal low-density lipoprotein removal from plasma as tested by the nanoemulsion method, but triglyceride removal was slower.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Nanopartículas
/
Emulsões Gordurosas Intravenosas
/
LDL-Colesterol
/
Obesidade
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2010
Tipo de documento:
Article