Immunomodulatory effect of mesenchymal stem cells
Braz. j. med. biol. res
;
43(5): 425-430, May 2010.
Artigo
em Inglês
| LILACS
| ID: lil-546330
ABSTRACT
Mesenchymal stem cells (MSC) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple mesenchymal tissues. MSC are able to reconstitute the functional human hematopoietic microenvironment and promote engraftment of hematopoietic stem cells. MSC constitutively express low levels of major histocompatibility complex-I molecules and do not express costimulatory molecules such as CD80, CD86 or CD40, thus lacking immunogenicity. Furthermore, they are able to suppress T- and B-lymphocyte activation and proliferation and may also affect dendritic cell maturation. Based on these properties, MSC are being used in regenerative medicine and also for the treatment of autoimmune diseases and graft-versus-host disease. On the other hand, MSC from patients diagnosed with myelodysplastic syndromes or multiple myeloma display abnormalities, which could play a role in the physiopathology of the disease. Finally, in patients with immune thrombocytopenic purpura, MSC have a reduced proliferative capacity and a lower inhibitory effect on T-cell proliferation compared with MSC from healthy donors.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Linfócitos T
/
Células-Tronco Mesenquimais
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Espanha
Instituição/País de afiliação:
Hospital Clínico Universitario de Salamanca/ES
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