Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats
J. appl. oral sci
; 18(3): 273-278, May-June 2010. ilus
Article
em En
| LILACS
| ID: lil-557093
Biblioteca responsável:
BR1.1
ABSTRACT
Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE:
The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL ANDMETHODS:
The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5 percent significance level.RESULTS:
Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells).CONCLUSIONS:
These results demonstrate that the COB cement induces less inflammatory response within long periods.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Materiais Biocompatíveis
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Hidróxido de Cálcio
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Óleo de Rícino
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Tela Subcutânea
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Agentes de Capeamento da Polpa Dentária e Pulpectomia
Limite:
Animals
Idioma:
En
Revista:
J. appl. oral sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article