Prevalence of common α -thalassemia determinants in south Brazil: importance for the diagnosis of microcytic anemia
Genet. mol. biol
; Genet. mol. biol;33(4): 641-645, 2010. tab
Article
em En
| LILACS
| ID: lil-571530
Biblioteca responsável:
BR1.1
ABSTRACT
Alpha thalassemia has not been systematically investigated in Brazil. In this study, 493 unrelated individuals from the southernmost Brazilian state of Rio Grande do Sul were screened for deletional forms of α-thalassemia. One hundred and one individuals had microcytic anemia (MCV < 80 fL) and a normal hemoglobin pattern (Hb A2 < 3.5 percent and Hb F < 1 percent). The subjects were screened for -α3.7,-α4.2,-α20.5, -SEA and -MED deletions but only the -α3.7 allele was detected. The -α3.7 allele frequency in Brazilians of European and African ancestry was 0.02 and 0.12, respectively, whereas in individuals with microcytosis the frequency was 0.20. The prevalence of α-thalassemia was significantly higher in individuals with microcytosis than in healthy individuals (p = 0.001), regardless of their ethnic origin. There were also significant differences in the hematological parameters of individuals with -α3.7/αα, -α3.7/α3.7 and β-thalassemia trait compared to healthy subjects. These data suggest that α-thalassemia is an important cause of microcytosis and mild anemia in Brazilians.
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Texto completo:
1
Índice:
LILACS
Assunto principal:
População
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Brasil
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Hemoglobinas
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Talassemia alfa
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Microcystis
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Genótipo
Tipo de estudo:
Diagnostic_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
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Brasil
Idioma:
En
Revista:
Genet. mol. biol
Assunto da revista:
GENETICA
Ano de publicação:
2010
Tipo de documento:
Article