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Internucleotide correlations and nucleotide periodicity in Drosophila mtDNA: New evidence for panselective evolution
Valenzuela, Carlos Y.
Afiliação
  • Valenzuela, Carlos Y; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Genetica Humana. Santiago. CL
Biol. Res ; 43(4): 481-486, 2010. tab
Article em En | LILACS | ID: lil-582864
Biblioteca responsável: BR1.1
ABSTRACT
Analysis for the homogeneity of the distribution of the second base of dinucleotides in relation to the first, whose bases are separated by 0, 1, 2,... 21 nucleotide sites, was performed with the VIH-1 genome (cDNA), the Drosophila mtDNA, the Drosophila Torso gene and the human p-globin gene. These four DNA segments showed highly significant heterogeneities of base distributions that cannot be accounted for by neutral or nearly neutral evolution or by the "neighbor influence" of nucleotides on mutation rates. High correlations are found in the bases of dinucleotides separated by 0, 1 and more number of sites. A periodicity of three consecutive significance values (measured by the x²9) was found only in Drosophila mtDNA. This periodicity may be due to an unknown structure or organization of mtDNA. This non-random distribution of the two bases of dinucleotides widespread throughout these DNA segments is rather compatible with panselective evolution and generalized internucleotide co-adaptation.
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Texto completo: 1 Índice: LILACS Assunto principal: DNA Mitocondrial / Deriva Genética / Drosophila / Mutação / Nucleotídeos Limite: Animals / Humans Idioma: En Revista: Biol. Res Assunto da revista: BIOLOGIA Ano de publicação: 2010 Tipo de documento: Article / Congress and conference

Texto completo: 1 Índice: LILACS Assunto principal: DNA Mitocondrial / Deriva Genética / Drosophila / Mutação / Nucleotídeos Limite: Animals / Humans Idioma: En Revista: Biol. Res Assunto da revista: BIOLOGIA Ano de publicação: 2010 Tipo de documento: Article / Congress and conference