STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
Braz. j. med. biol. res
; 44(11): 1080-1087, Nov. 2011. ilus
Article
em En
| LILACS
| ID: lil-604269
Biblioteca responsável:
BR1.1
ABSTRACT
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
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Texto completo:
1
Índice:
LILACS
Assunto principal:
Canais de Cálcio
/
Cálcio
/
Sinalização do Cálcio
/
Proteínas de Membrana
/
Proteínas de Neoplasias
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article