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E-cadherin and c-Met expression in actinic cheilits and lip squamous cell carcinoma
Martínez, A; Spencer, M. L; Borlando, J; Flores, M; Rojas, I. G.
Afiliação
  • Martínez, A; University of Concepción. College of Medicine. School of Dentistry. Departments of Oral Pathology. CL
  • Spencer, M. L; University of Concepción. College of Medicine. School of Dentistry. Departments of Oral Pathology. CL
  • Borlando, J; University of Concepción. College of Medicine. School of Dentistry. Departments of Pathology. CL
  • Flores, M; University of Concepción. College of Medicine. School of Dentistry. Departments of Public Health. CL
  • Rojas, I. G; University of Concepción. College of Medicine. School of Dentistry. Departments of Oral Surgery. CL
Rev. clín. periodoncia implantol. rehabil. oral (Impr.) ; 4(3): 122-125, dic. 2011. ilus
Article em En | LILACS | ID: lil-627549
Biblioteca responsável: CL1.1
ABSTRACT

Objective:

The aim of this study was to assess epithelial expression of E-cadherin and c-Met in normal lip, in actinic cheilitis and lip squamous cell carcinoma. Study

Design:

Biopsies of normal lip vermillion (NL, n=18), actinic cheilitis (AC, n=37), and lip SCC (n=22) were processed for E-cadherin and c-Met immunodetection. Epithelial and tumor cell expression was scored for each sample considering staining intensity and percentage.

Results:

E-cadherin expression was significantly reduced in AC and lip SCC as compared to normal lip (P<0.05), with a significant reduction in lip SCC as compared to AC (P=0.003). Expression of c-Met was significantly higher in AC and lip SCC as compared to NL (P<0.05), with a significant increase in lip SCC as compared to AC (P<0.0001).

Conclusion:

The results showed that epithelial E-cadherin expression is reduced and c-Met expression is increased as lip carcinogenesis progresses, suggesting that these proteins may be useful markers of malignant transformation.
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Texto completo: 1 Índice: LILACS Assunto principal: Neoplasias Labiais / Carcinoma de Células Escamosas / Caderinas / Queilite / Proteínas Proto-Oncogênicas c-met Limite: Humans Idioma: En Revista: Rev. clín. periodoncia implantol. rehabil. oral (En línea) / Rev. clín. periodoncia implantol. rehabil. oral (Impr.) / Revista clínica de periodoncia, implantología y reabilitación oral (Impresa) Assunto da revista: ODONTOLOGIA Ano de publicação: 2011 Tipo de documento: Article / Project document
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Índice: LILACS Assunto principal: Neoplasias Labiais / Carcinoma de Células Escamosas / Caderinas / Queilite / Proteínas Proto-Oncogênicas c-met Limite: Humans Idioma: En Revista: Rev. clín. periodoncia implantol. rehabil. oral (En línea) / Rev. clín. periodoncia implantol. rehabil. oral (Impr.) / Revista clínica de periodoncia, implantología y reabilitación oral (Impresa) Assunto da revista: ODONTOLOGIA Ano de publicação: 2011 Tipo de documento: Article / Project document