Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños / Association of metabolic syndrome markers with abnormal alanine aminotransferase levels in healthy children
Rev. méd. Chile
; 140(7): 896-901, jul. 2012. ilus
Article
em Es
| LILACS
| ID: lil-656361
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ABSTRACT
Background:
There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment.Aim:
To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness. Subjects andMethods:
A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels.Results:
Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multiva-riate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008).Conclusions:
Only waist obesity was independently associated with abnormal ALT levels in this sample of children.Palavras-chave
Texto completo:
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Índice:
LILACS
Assunto principal:
Síndrome Metabólica
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Alanina Transaminase
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Fígado Gorduroso
Tipo de estudo:
Clinical_trials
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
País/Região como assunto:
America do sul
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Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
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Project document