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Neoplasias epiteliales del timo: timoma y carcinoma tímico: caracterización, tratamiento y variables asociadas a supervivencia / Thymic epithelial tumors. Retrospective review of 54 patients
González L., Roberto; Santolaya C., Raimundo; Jadue T., Andrés; Prats M., Rafael; Mordojovich R., Gerardo; Rodríguez D., Patricio.
Afiliação
  • González L., Roberto; s.af
  • Santolaya C., Raimundo; s.af
  • Jadue T., Andrés; s.af
  • Prats M., Rafael; s.af
  • Mordojovich R., Gerardo; s.af
  • Rodríguez D., Patricio; s.af
Rev. chil. cir ; 64(6): 535-545, dic. 2012. graf, tab
Article em Es | LILACS | ID: lil-660012
Biblioteca responsável: CL1.1
ABSTRACT

Background:

Thymic epithelial tumors are uncommon and can be associated with myasthenia gravis.

Aim:

To describe variables associated with survival and treatment of thymic epithelial tumors. Material and

Methods:

Retrospective review of surgical databases of a respiratory diseases hospital, identifying patients operated for a thymic epithelial tumor between 2000 and 2010. Follow up lasted from 12 to 156 months and information was obtained from medical records and death certificates of the Chilean national identification service.

Results:

Data from 54 patients aged 52.5 +/- 16.4 years (33 women) was retrieved. Forty two patients were symptomatic and 47 were subjected to resective surgery. The pathological diagnosis was thymoma in 46 cases and thymic carcinoma in eight. Fourteen patients had postoperative complications and one died. Mean survival time was 101.8 +/- 10.2 months. One, three and five years survival was 90.7 +/- 3.9, 81.4 +/- 5.7 and 71.8 +/- 8.2 percent, respectively. Preoperative performance status of patients, histological type of the tumor and associated myasthenia gravis were predictors of survival.

Conclusions:

More commonly, thymic epithelial tumors appear in women, their histological type corresponds to thymomas and their resection is feasible.
RESUMEN

Objetivos:

Describir características, tratamiento y variables asociadas a supervivencia de neoplasias epiteliales del Timo (NET). Material y

Método:

Revisión retrospectiva de pacientes con NET. Período enero de 2000 - agosto de 2010. Se describen características, tratamiento, morbilidad, mortalidad y supervivencia global. Se comparó supervivencias según variables seleccionadas. Se utilizó programa SPSS 15.0. Se consideró significativo p < 0,05.

Resultados:

54 pacientes, 33 mujeres, edad promedio 52,5 años. Sintomáticos 42 pacientes. Se realizó cirugía resectiva en 47. Histología 46 Timomas y 8 Carcinomas Tímicos. Complicaciones en 14 y 1 falleció. Rango seguimiento 12-156 meses. Tiempo promedio supervivencia 101,8 +/- 10,2 meses. Supervivencia global a 1, 3 y 5 años 90,7 +/- 3,9 por ciento, 81,4 +/- 5,7 por ciento y 71,8 +/- 8,2 por ciento respectivamente. Se encontraron variables asociadas a supervivencia.

Conclusiones:

Las NET son más frecuentes en mujeres, la mayoría son sintomáticos e histológicamente son timoma. La cirugía es resectiva en la mayoría. Se identifican variables asociadas a supervivencia.
Assuntos
Palavras-chave

Texto completo: 1 Índice: LILACS Assunto principal: Timoma / Neoplasias do Timo / Carcinoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: Es Revista: Rev. chil. cir Assunto da revista: CIRURGIA GERAL Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Índice: LILACS Assunto principal: Timoma / Neoplasias do Timo / Carcinoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: Es Revista: Rev. chil. cir Assunto da revista: CIRURGIA GERAL Ano de publicação: 2012 Tipo de documento: Article