Utilidad de la adenosina deaminasa (ADA): interferón gamma y biopsia pleural para el diagnóstico de tuberculosis pleural / Efficacy of the adenosine deaminase: interferon gamma and pleural biopsy for the diagnosis of pleural tuberculosis
Gac. méd. Caracas
; 120(3): 187-196, jul.-sept. 2012. tab
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| ID: lil-706246
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RESUMEN
El diagnóstico de la tuberculosis pleural es difícil usando solo los métodos convencionales. El objetivo de este trabajo es demostrar la eficacia de la adenosina deaminasa, interferón gamma y biopsia pleural para el diagnóstico de tuberculosis pleural y si estos biomarcadores podrían obviar la práctica de la biopsia. Se realizó el estudio prospectivo de 52 muestras de líquido pleural y 54 biopsias pleurales de 52 pacientes (M/F 30/22). La edad promedio fue 38,8 ± 20,6 años. Los derrames fueron tuberculosis pleural, 33 (63,46%), asociados a infección respiratoria baja. 10 (19,23%) y 9 neoplásicos (17,30%). La sensibilidad de interferon gamma, adenosina deaminasa y biopsia fue de 88,0%, 76,0% y 65,0%, respectivamente y especificidad de 78,0%, 63,0% y 100,0% respectivamente. Conclusiones:
la adenosina deaminasa no es util aislada como método diagnóstico para la tuberculosis pleural. Se recomienda no obviar el cultivo ni la biopsia plaural y siendo Venezuela un país de alta prevalencia de tuberculosis, hacer de rutina, la medición de interferón gamma y la toracoscopia.ABSTRACT
The diagnosis of pleural tuberculous is difficult using only conventional methods. The aim of this paper is to demostrate the efficacy of the adenosine deaminase Interferon gamma and pleural biopsy for the diagnosis of pleural tuberculosis and if these biomarkers could ignore the practice of the biopsy. The prospective study of 52 samples of pleural fluid and 54 pleural biopsies of 52 patients was conducted. The median age was 38.8 (20.6 years.). Tuberculosis etiology spills were 33 (63.46%) associated with low respiratory infection 10 (19.23%) and 9 neoplastic (17,30%). The sensitivity of Interferon gamma, adenosine deaminase and biopsy was 88.0%, 76.0% to 65.0% respectively and the specificity was 78.0% and 63.0% 100.0% respectively. Conclusions:
the adenosine deaminase is not useful only as a diagnostic method for the pleural tuberculosis. It is recommended to not override the cultivation or do the pleural biopsy and being Venezuela as a country of high prevalence of tuberculosis. make routine, the measurement of gamma interferon and the thoracoscopy it is recommended.Palavras-chave
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Índice:
LILACS
Assunto principal:
Infecções Respiratórias
/
Toracoscopia
/
Tuberculose Pleural
/
Adenosina Desaminase
/
Interferon gama
/
Inibidores de Adenosina Desaminase
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Gac. méd. Caracas
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article