Efecto de la ingesta aguda de vanillina sobre la resistencia insulínica en humanos / Effect of a single oral dose of vanillin on insulin resistance in humans
Rev. chil. endocrinol. diabetes
; 6(1): 6-11, ene. 2013. ilus, tab, graf
Article
em Es
| LILACS
| ID: lil-726582
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
NADPH oxidase is a source of reactive oxygen species that may contribute to insulin resistance (IR).Aim:
To assess the effect of a single oral dose of vanillin (a putative inhibitor of the enzyme) on IR in humans. Material andMethods:
Using a crossover, random, double-blind design, eight lean and 10 obese males ingested 600 mg of vanillin or placebo followed by the ingestion of 75g of glucose. Serum/plasma glucose, free-fatty acids, insulin, glutathione, C reactive protein concentrations and red blood cell glutathione concentration were determined. Insulin resistance was estimated by the Matsuda index.Results:
Under fasting conditions, obese individuals had higher glucose and insulin and lower red blood cell glutathione levels than their lean counterparts (p < 0.01). Serum free-fatty acids, total and oxidized plasma glutathione concentrations were similar in both groups. After glucose ingestion, obese individuals had a lower red blood cell total glutathione concentration and increased plasma oxidized glutathione concentration than their lean counterparts (p < 0.05). In addition, obese participants had a higher level of IR (p < 0.001) and impaired serum free-fatty acid suppression (p < 0.001) than their lean counterparts. Ingestion of vanillin did not modify any of these variables when compared with placebo in obese individuals. In lean volunteers a reduction in Matsuda index was detected when vanillin was administered, compared to placebo (4.3 +/- 0.6 and 3.6 +/- 0.6 respectively; p < 0.05).Conclusions:
IR was ameliorated after vanillin ingestion among lean but not obese participants.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Benzaldeídos
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Resistência à Insulina
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Antioxidantes
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Obesidade
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Humans
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Male
Idioma:
Es
Revista:
Rev. chil. endocrinol. diabetes
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
/
Project document