Comparative study of collagen deposition in the colon wall of patients operated for sigmoid diverticular disease
Acta cir. bras
; 30(10): 715-719, tab, graf
Article
em En
| LILACS
| ID: lil-764394
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate the deposition of collagen in the colon wall of patients with sigmoid diverticulitis.METHODS:
Samples of sigmoid tissue from 15 patients (disease group), seven men and eight women aged 37-77 years who underwent surgery for the treatment of diverticulitis, were selected. For the control group, specimens from five patients, three men and two women aged 19-58 years undergoing emergency surgery for sigmoid trauma were selected. These subjects had no associated diseases. The histological study of the surgical specimens was performed by staining with hematoxylin-eosin and picrosirius and using a histochemical method for collagen quantification.RESULTS:
Collagen deposition in the colon wall in terms of area (F), glandular epithelium (E) and total area was significantly higher in the disease group compared to control (p=0.003, p=0.026 and p=0.010, respectively). The collagen volume fraction (F fraction) and muscle tissue (M fraction) were also significantly higher compared to control (p=0.044 and p=0.026, respectively). The muscle (M area) and volume fraction of glandular epithelium (E fraction) did not differ significantly between the two groups, (p=0.074 and p=1.000, respectively).CONCLUSION:
In this study, collagen deposition in the colon wall of the patients operated for sigmoid diverticulitis was higher compared to patients without the disease.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Doenças do Colo Sigmoide
/
Colo Sigmoide
/
Colágeno
/
Doença Diverticular do Colo
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2015
Tipo de documento:
Article