Rutin ameliorates methotrexate induced hepatic injury in rats
Acta cir. bras
; 30(11): 778-784, Nov. 2015. tab, graf
Article
em En
| LILACS
| ID: lil-767597
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats.METHODS:
Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum.RESULTS:
Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx +Rutin group. Serum AST levels were similar among the groups.CONCLUSION:
Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.Palavras-chave
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LILACS
Assunto principal:
Rutina
/
Metotrexato
/
Doença Hepática Induzida por Substâncias e Drogas
/
Imunossupressores
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2015
Tipo de documento:
Article