Effect of acute bromopride treatment on rat prolactin levels and sexual behavior

RESUMO

Acute intraperitoneal adminsitration of bromoprid (BRO), a dopamine D2 blocker used as an anti-emetic drug in gastroenterology was tested in male and female ratas for its effect on prolactin (PRL) serum levels and on sexual behavior. Rats that received 2.5 mg/Kg BRO, the lowest dose tested, showed a maximal nincrease in PRL serum levels. Male rats that received 5.0 mg/Kg BRO showed higher postejaculatory mount lactency and postejaculatory intromission latency than controls. Rats treated with 10.0 mg/Kg BRO showed higher mount latency, intromission latency, ejaculation latency, postejaculatory mount latency and a lower percentage of animals showing mount and ejaculation. Female rats that received 5.0 mg/Kg BRO showed a lower lordosis quotient. The data suggest that glockade of postynaptic dopamine D2 receptors inhibitis male and female sexual behavior and that this inhibition is not related solely to the increase in PRL lelvels