Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease
Acta cir. bras
; 31(8): 527-532, Aug. 2016. graf
Article
em En
| LILACS
| ID: lil-792410
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease.METHODS:
Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control) distilled water. Group 2 (Azuki) Vigna angularis 5% aqueous extract. Group 3 (Treatment) 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days.RESULTS:
The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group.CONCLUSION:
Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Extratos Vegetais
/
Insuficiência Renal Crônica
/
Vigna
/
Fitoterapia
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Article