Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 38(4): 301-306, Oct.-Dec. 2016. tab
Article
em En
| LILACS
| ID: lil-798085
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis.Methods:
A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical, and biochemical variables were evaluated after a midweek hemodialysis session. The participants’ body composition was assessed by direct segmental multi-frequency bioimpedance analysis. The WHOQOL-Bref questionnaire was used to evaluate QoL. Participants were separated into two groups - depressive symptoms and no depressive symptoms - at inclusion and evaluated annually for 2 years thereafter using the Beck Depression Inventory. Survival analysis used the Kaplan-Meier method and Cox regression analysis for the goodness of fit of associated factors. All-cause mortality was the outcome of interest.Results:
Participants’ mean age was 55.3±15.6 years, 60% were male, and the median time on hemodialysis was 17.5 (8.0-36.8) months. Thirty-two patients had depressive symptoms and a significantly lower QoL compared with the 72 patients in the no depressive symptoms group. The fitted outcome model showed that lean body mass had a protective effect against all-cause mortality (hazard ratio [HR] = 0.89; 95%CI 0.80-0.99; p = 0.038).Conclusion:
Depressive symptoms were highly prevalent in the cohort, and correlated with the physical and psychological components of the QoL life questionnaire, as well as with C-reactive protein and phosphorus levels. Lean body mass was protective for the assessed outcome.Palavras-chave
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LILACS
Assunto principal:
Qualidade de Vida
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Composição Corporal
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Estado Nutricional
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Diálise Renal
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Depressão
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Falência Renal Crônica
Tipo de estudo:
Etiology_studies
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Observational_studies
/
Prognostic_studies
/
Qualitative_research
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Risk_factors_studies
Limite:
Adult
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Aged
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Humans
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Male
Idioma:
En
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2016
Tipo de documento:
Article