Isotypic distribution of antibody responses in lines of mice selected for high or low immunoresponsiveness
Braz. j. med. biol. res
;
24(4): 407-16, 1991. tab
Artigo
em Inglês
| LILACS
| ID: lil-99470
ABSTRACT
The isotype distribution of antibody (Ab) responses to Salmonella antigens (Ag) was investigated in high (H) and low (L) Ab responder lines of mice from Selections III and carried out for responsiveness to flagellar (f) and somatic (s) Ag, respectively. Primary immuniztion resulted in higher Ab titers of all isotypes in response to both Ag in H mice fro m both selections and was confirmed after booster injections. The interline difference (H-L) in response to the distinct isotypes ranged from 3.0 to 7.0 log2 to Ag f in Selection III and from 2.0 to 5.1 log2 to Ag s in Selection IV. Comparison of isotype production to 3 Ag in Selections I,II,III and IV demonstrated that 1) the highest responses in all mice are those against the selection Ag, 2) the isotypic pattern depends on both the Ag injected and the host's genetic constitution, and 3) the presence or lack of a multispecific effect is not due to isotype-restricted regulation
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Índice:
LILACS (Américas)
Assunto principal:
Salmonella typhimurium
/
Isotipos de Imunoglobulinas
/
Genes MHC da Classe II
/
Antígenos de Bactérias
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
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