Pharmacokinetics of phenytoin: unaltered by enalapril and amlodipine in rhesus monkeys.
Indian J Physiol Pharmacol
; 1999 Apr; 43(2): 251-4
Article
em En
| IMSEAR
| ID: sea-106808
ABSTRACT
A cross over single and multiple dose study was carried out to find out pharmacokinetic interactions between diphynylhydantoin (DPH) (35 mg/kg, p.o.) and antihypertensives enalapril (1.6 mg/kg; p.o.) and amlodipine (0.4 mg/kg, p.o.) in rhesus monkeys. Neither the plasma concentrations nor the pharmacokinetic parameters of DPH were altered by coadministration of enalapril or amlodipine, suggesting that enalapril and amlodipine can be safely administered to epileptic patients receiving phenytoin.
Texto completo:
1
Índice:
IMSEAR
Assunto principal:
Fenitoína
/
Masculino
/
Enalapril
/
Anlodipino
/
Estudos Cross-Over
/
Interações Medicamentosas
/
Animais
/
Macaca mulatta
/
Anticonvulsivantes
/
Anti-Hipertensivos
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1999
Tipo de documento:
Article