Studies on anti-inflammatory, analgesic and antipyretic activities of some indan acids.
Indian J Physiol Pharmacol
; 1980 Oct-Dec; 24(4): 310-6
Article
em En
| IMSEAR
| ID: sea-106985
ABSTRACT
A series of indan-1 acids were synthesized and screened for anti-inflammatory activity. All the reported compounds showed varying degrees of anti-inflammatory activity in carrageenin-induced paw oedema test. They also exhibited appreciable antipyretic and analgesic activity in various animal test models. Among these compounds 6-methoxy-indan-1-acetic acid (compound 11) and 5,6-dimethoxy-indan-1-acetic acid (compound 12) showed activity profile close to that of phenylbutazone having prolonged action and lower toxicity than the latter.
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IMSEAR
Assunto principal:
Ratos
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Masculino
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Anti-Inflamatórios não Esteroides
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Indanos
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Indenos
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Dose Letal Mediana
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Animais
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Camundongos
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1980
Tipo de documento:
Article