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Effect of the 5-HT3 receptor antagonist ondansetron on amphetamine-induced hyperactivity and stereotypy in rats.
Indian J Physiol Pharmacol ; 2000 Jul; 44(3): 355-8
Article em En | IMSEAR | ID: sea-107199
ABSTRACT
The effects of different doses of ondansetron (0.1, 0.5, 1, 2 mg/kg) administered intra-peritoneally were studied on amphetamine-induced hyperactivity and stereotypy in wistar rats. Ondansetron was administered 30 minutes prior to d-amphetamine (3 mg/kg, i.p.). Ondansetron in doses of 0.5 and 1 mg/kg significantly decreased the mean number of head dippings and crossings in the hole board test and in doses of 0.1 and 0.5 mg/kg significantly decreased the average stereotypic score. Since the hyperactivity and stereotypy are dopamine mediated, the effect of ondansetron to reduce these states suggests a potential role for ondansetron in conditions with dopamine excess.
Assuntos
Texto completo: 1 Índice: IMSEAR Assunto principal: Ratos / Antagonistas da Serotonina / Comportamento Estereotipado / Masculino / Receptores de Serotonina / Ratos Wistar / Ondansetron / Receptores 5-HT3 de Serotonina / Dextroanfetamina / Animais Idioma: En Revista: Indian J Physiol Pharmacol Ano de publicação: 2000 Tipo de documento: Article
Texto completo: 1 Índice: IMSEAR Assunto principal: Ratos / Antagonistas da Serotonina / Comportamento Estereotipado / Masculino / Receptores de Serotonina / Ratos Wistar / Ondansetron / Receptores 5-HT3 de Serotonina / Dextroanfetamina / Animais Idioma: En Revista: Indian J Physiol Pharmacol Ano de publicação: 2000 Tipo de documento: Article