Vitamin E protects intestinal basolateral membrane from CMF-induced damages in rat.
Indian J Physiol Pharmacol
; 1995 Jul; 39(3): 263-6
Article
em En
| IMSEAR
| ID: sea-107956
ABSTRACT
CMF is a combination of anticancer chemotherapeutic agents Cyclophosphamide, Methotrexate and 5-Fluorouracil. Vitamin E protects the basolateral membrane (BSM) from CMF induced lipid peroxidative damages. Rats were treated intravenously with cyclophosphamide-10 mg, methotrexate-1.0 mg and 5-fluorouracil-10 mg per kg body weight for six cycles. Vitamin E (600 mg/kg body weight) was administered orally, daily. Intestinal basolateral membrane bound ATPases (3.6.1.3), Alkalinephosphatase (3.1.1) and 5'-Nucleotidase (3.1.3.5) were protected by co-administration of vitamin E with CMF. In CMF treated rats the lipid peroxidation levels were found to be elevated with a significant depletion in membrane sulfhydryl groups. In vitamin E co-administered animals, the enzyme activities were found to be restored with concomitant reduction in malondialdehyde levels and an increase in the sulfhydryl groups. The membrane cholesterol and phospholipid levels which were altered in CMF treated rats were bought back to the normal in co-administration of vitamin E.
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1
Índice:
IMSEAR
Assunto principal:
Ratos
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Vitamina E
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Masculino
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Tireotropina
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Protocolos de Quimioterapia Combinada Antineoplásica
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Metotrexato
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Ratos Wistar
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Ciclofosfamida
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Metabolismo dos Lipídeos
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Fluoruracila
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1995
Tipo de documento:
Article