GABAergic agents modify imipramine analgesia.
Indian J Physiol Pharmacol
; 1996 Jan; 40(1): 95-7
Article
em En
| IMSEAR
| ID: sea-108083
The influence of GABA agonists and antagonists on analgesic activity of imipramine (IMA, 20 mg/kg, ip) was studied using the hotplate method. Administration of GABAA receptor agonist muscimol (1 mg/kg, ip), GABAB receptor agonist baclofen (3 mg/kg, ip) or GABA-T inhibitor aminooxyacetic acid (25 mg/kg, ip) increased the analgesic effect of IMA. On the other hand pretreatment of GABAA receptor antagonist bicucukline (2 mg/kg ip), GABAB receptor antagonist delta-amino-n-valeric acid (50 mg/kg, ip) or GABA synthesis inhibitor thiosemicarbazide (50 mg/kg, ip) attenuated the IMA analgesia. These results suggest that the analgesic action of IMA may be mediated by functional alteration of a central GABAergic mechanism and/or subsequent stimulation of GABA receptors.
Texto completo:
1
Índice:
IMSEAR
Assunto principal:
Feminino
/
Masculino
/
Receptores de GABA-B
/
Receptores de GABA-A
/
Antagonistas GABAérgicos
/
Agonistas GABAérgicos
/
GABAérgicos
/
Analgésicos não Narcóticos
/
Inibidores Enzimáticos
/
4-Aminobutirato Transaminase
Idioma:
En
Revista:
Indian J. physiol. pharmacol
Ano de publicação:
1996
Tipo de documento:
Article