Role of nitric oxide on insulin induced seizures in mice.
Indian J Physiol Pharmacol
; 1999 Jul; 43(3): 373-7
Article
em En
| IMSEAR
| ID: sea-108224
ABSTRACT
The role of nitric oxide (NO) on acute hypoglycemia-induced seizures in mice was investigated using insulin as the hypoglycemic agent. The NO precursor L-arginine in the doses of 150, 500 and 750 mg/kg exhibited a dose-dependent protective effect against seizures induced by 8 mu/kg insulin. The NO synthase inhibitor (L-NMMA) at the doses of 50 and 100 mg/kg potentiated the subconvulsive doses of insulin (2 mu/kg). The onset, duration, number of seizures and the mortality were noted in a 2 hr study period. The results of this study suggest than NO plays an important protective role in acute hypoglycemia induced seizures which are known to occur through the activation of NMDA receptors.
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Assunto principal:
Arginina
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Convulsões
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Masculino
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Receptores de N-Metil-D-Aspartato
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ômega-N-Metilarginina
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Doadores de Óxido Nítrico
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Relação Dose-Resposta a Droga
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Hipoglicemia
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Insulina
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Animais
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1999
Tipo de documento:
Article