Delayed manifestation of ultra violet radiation induced erythema in guinea pigs by sodium pyruvate--a free radical scavenger.
Indian J Physiol Pharmacol
; 1998 Apr; 42(2): 315-8
Article
em En
| IMSEAR
| ID: sea-108547
ABSTRACT
Sodium pyruvate, a free radical scavenger was evaluated for anti-inflammatory activity using UV radiation induced dermal erythema on guinea pig and compared with that of standard naproxen. Oral as well as topical pyruvate exhibited significant activity against UV induced dermal erythema model and the activity was comparable to that of naproxen. In the other pharmacodynamic studies, such as the studies on rat blood pressure, isolated guinea pig ileum and rat uterus, it showed no effect on any of these. In conclusion, sodium pyruvate showed a significant protection in the UV induced dermal erythema in guinea pigs. It also showed good absorption in UV-B range and this property can be utilised to develop the sodium pyruvate as a sunscreening agent.
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Assunto principal:
Protetores Solares
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Raios Ultravioleta
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Anti-Inflamatórios não Esteroides
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Naproxeno
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Sequestradores de Radicais Livres
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Ácido Pirúvico
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Eritema
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Cobaias
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Animais
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1998
Tipo de documento:
Article