Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness.
Indian J Physiol Pharmacol
; 1995 Jul; 39(3): 299-301
Article
em En
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| ID: sea-108583
ABSTRACT
Intracerebral microinjections of gamma amino butyric acid were given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotransmitter in the genesis and regulation of sleep-wakefulness. GABA (50 micrograms/0.2 microliters) when administered through chronically implanted cannulae in free moving rats, did not produce any significant alterations in sleep-wakefulness. This may be attributed either to the non-involvement of GABA at the level of mPOA in the regulation of sleep, or to other factors like the low dose and rapid breakdown of the injected drug.
Texto completo:
1
Índice:
IMSEAR
Assunto principal:
Área Pré-Óptica
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Ratos
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Sono
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Vigília
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Masculino
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Ratos Wistar
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Eletroencefalografia
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Ácido gama-Aminobutírico
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Animais
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
1995
Tipo de documento:
Article