Calcium-transporters in myocardial cells.
Indian J Physiol Pharmacol
; 2006 Apr-Jun; 50(2): 99-113
Article
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| IMSEAR
| ID: sea-108723
ABSTRACT
This is a concise review of important calcium-transporters on the sarcolemma and organellar membranes of myocardial cells, and their functional roles in cell physiology. It briefly addresses L and T type calcium channels, store-operated calcium channel (SOC), sodium-calcium exchanger (NCX), and the plasma membrane calcium ATPase (PMCA) on the sarcolemma, ryanodine receptor (RyR), IP3 receptor (IP3R) and the sarcoplasmic reticulum (SR) calcium ATPase (SAERCA) on the SR membrane and their contributions to contraction and rhythm-generation. Several agonists and blockers for every transporter that are commonly used in research, and those with therapeutic applications have also been discussed.
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Assunto principal:
Sarcolema
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Humanos
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Canais de Cálcio
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ATPases Transportadoras de Cálcio
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Receptores Citoplasmáticos e Nucleares
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Canal de Liberação de Cálcio do Receptor de Rianodina
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Trocador de Sódio e Cálcio
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Canais de Cálcio Tipo L
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Canais de Cálcio Tipo T
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Proteínas de Transporte de Cátions
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2006
Tipo de documento:
Article