Effect of nimodipine on male reproductive functions in rats.
Indian J Physiol Pharmacol
; 2000 Oct; 44(4): 449-55
Article
em En
| IMSEAR
| ID: sea-108734
ABSTRACT
Nimodipine, a dihydropyridine calcium channel blocker, was administered orally using two different doses (40 mg and 60 mg/kg/day) to rats. Both short term (2 weeks) and long term (6 weeks) effects of the drug were observed. The drug administration resulted in a marked decrease in sperm density, sperm motility and acrozomal reaction. Zona-pellucida penetration by the sperm obtained from drug-treated animals was significantly lower when compared with sperm from normal animals. Nimodipine stimulated Ca2+ ATPase activity in isolated plasma membrane of rate spermatozoa. In conclusion, short term and long term administration of nimodipine has deleterious effect on male reproductive functions in rats.
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Assunto principal:
Ratos
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Reprodução
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Contagem de Espermatozoides
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Motilidade dos Espermatozoides
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Zona Pelúcida
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Feminino
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Masculino
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Bloqueadores dos Canais de Cálcio
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Nimodipina
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ATPases Transportadoras de Cálcio
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2000
Tipo de documento:
Article