Effect of ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats.
Indian J Physiol Pharmacol
; 2005 Oct-Dec; 49(4): 422-6
Article
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| IMSEAR
| ID: sea-108797
ABSTRACT
We studied effect of exogenous ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on serum lipids and proteins in experimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6 g/kg/day) for 28 days. Both preventive and curative options were studied. Percentage increase in body weight was significantly lower in ethanol treated rats. Ethanol significantly (P<0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and AG ratio in serum. Ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect.
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Assunto principal:
Fosfatidilcolinas
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Ácido Ascórbico
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Ratos
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Peso Corporal
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Masculino
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Depressores do Sistema Nervoso Central
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Ratos Wistar
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Alfa-Tocoferol
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Dipeptídeos
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Etanol
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Ano de publicação:
2005
Tipo de documento:
Article