Pathology of temporal lobe epilepsy: An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy.
Neurol India
; 1999 Sep; 47(3): 196-201
Article
em En
| IMSEAR
| ID: sea-120548
ABSTRACT
The neuropathological features of temporal lobe epilepsy were studied utilising 100 consecutive surgical specimens from patients with medically refractory complex partial seizures. A wide spectrum of neuropathological changes was recorded in 98 specimens. Fifty-eight specimens showed features of Ammon's horn sclerosis. Diffuse accumulation of corpora amylacea were demonstrated in the resected temporal lobes from 54 patients. Six patients had neoplastic lesions of temporal lobe. One unique case of dysembryoplastic neuroepithelial tumour showed a melanotic component within the tumour. The neuropathological features were regarded as nonspecific in 31% of cases. Our results indicate that a majority of patients with medically intractable epilepsy of temporal lobe origin reveal significant neuropathological features. Careful documentation of the neuropathological features and its correlation with radiological, electrophysiological and pre- and post-surgical clinical features will help in predicting the seizure outcome after temporal lobectomy for medically refractory epilepsy.
Texto completo:
1
Índice:
IMSEAR
Assunto principal:
Esclerose
/
Lobo Temporal
/
Neoplasias Encefálicas
/
Humanos
/
Epilepsia do Lobo Temporal
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Hipocampo
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Neurol India
Ano de publicação:
1999
Tipo de documento:
Article