ANTI-PROLIFERATIVE AND CYTOTOXIC EFFECTS OF MURDANNIA LORIFORMIS ON LEUKEMIC CELL LINES

ABSTRACT

AbstractMurdannia loriformis (Hassk.) Rolla Rao et Kammathy is widely used in Thailand to treat cancer  patients. This study aimed to investigate anti-proliferative and cytotoxic effects of water and 80% ethanolic extracts of M. loriformis on five types of leukemic cell lines [Promyelocytic leukemia (HL60), T-cell leukemia (Molt4), B-cell leukemia (Daudi), Monocytic  leukemia (U937) and Erythroleukemia (K562)]. Both water and 80% ethanolic extracts (50-400 μ g/mL of extracts) did not show any anti-proliferative and cytotoxic effects on all tested types of leukemic cell lines. Chiang Mai Med Bull 2001;40(4)195-203.