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Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population.
Article em En | IMSEAR | ID: sea-135597
ABSTRACT
Background &

objective:

Renin-angiotensin aldosterone system (RAAS) plays an important role in the regulation of blood pressure. Aldosterone, synthesized by aldosterone synthase in the adrenal cortex is encoded by the CYP11B2 gene. In this case-control study we examined the association between CYP11B2 C-344T polymorphism and essential hypertension in south Indian Tamil population.

Methods:

The study was conducted in 406 hypertensive cases and 424 healthy controls from Tamil population. Genotyping was performed by PCR-restriction fragment length polymorphism method. Statistical analysis was performed by logistic regression analysis.

Results:

The 344TT homozygous variant genotype (OR-1.8; 95% CI 1.1-2.8; P=0.02) and T allele (P=0.007) were found to be significantly associated with hypertension. In gender based analysis, the risk was significantly higher in male hypertensives (OR-1.8; 95% CI 1.0-3.6, P=0.05) but not in female subjects. Interpretation &

conclusion:

A significant association between CYP11B2 gene polymorphism and essential hypertension was observed and the risk was confined to male subjects in south Indian Tamil population.
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Texto completo: 1 Índice: IMSEAR Assunto principal: Sistema Renina-Angiotensina / Feminino / Humanos / Masculino / Etnicidade / Modelos Logísticos / Razão de Chances / Primers do DNA / Citocromo P-450 CYP11B2 / Adulto Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies País/Região como assunto: Asia Idioma: En Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Índice: IMSEAR Assunto principal: Sistema Renina-Angiotensina / Feminino / Humanos / Masculino / Etnicidade / Modelos Logísticos / Razão de Chances / Primers do DNA / Citocromo P-450 CYP11B2 / Adulto Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies País/Região como assunto: Asia Idioma: En Ano de publicação: 2010 Tipo de documento: Article