Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: A study from Central India.
Indian J Med Microbiol
; 2010 Oct-Dec; 28(4): 358-362
Article
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| IMSEAR
| ID: sea-143739
ABSTRACT
Characterisation of host immune response to hepatitis C virus (HCV) genotypes may have an important prognostic and therapeutic implication. Genotype-3 was more prevalent in the examined cohort and demonstrated a significantly higher response to combination therapy than genotype-1. Sustained virological response (SVR) was 94.74% in genotype-3 and 45.45% in genotype-1. The patients who achieved SVR reported higher levels of circulating T helper 1 cytokines in comparison to subjects with no SVR in both the studied groups. Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients.
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IMSEAR
Tipo de estudo:
Prevalence_studies
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Risk_factors_studies
Idioma:
En
Revista:
Indian J Med Microbiol
Assunto da revista:
Microbiology
Ano de publicação:
2010
Tipo de documento:
Article